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肺炎克雷伯氏菌毒力因子及其基因组学研究进展
赵位,喻东,程建国,李秋波,王印,杨泽晓,姚学萍,罗燕
0
(四川农业大学动物医学院,成都 611130;四川养麝研究所,都江堰 611800)
摘要:
肺炎克雷伯氏菌(Klebsiella pneumoniae)属于肠杆菌科、克雷伯菌属,在人和动物肠道、呼吸道以及水、土壤、林产品和农产品中广泛存在,肺炎克雷伯氏菌作为一种机会致病菌,是目前公认的导致人和动物发病的重要革兰阴性菌。该菌可引起宿主感染肺炎、肝脓肿、脑膜炎、肠炎、子宫炎、乳腺炎及败血症。此外,随着测序技术的发展,全基因组序列分析已经广泛应用于探究肺炎克雷伯氏菌入侵以及抵抗宿主免疫系统引起致病的研究。对肺炎克雷伯氏菌毒力因子荚膜(Capsule)、脂多糖(Lipopolysaccharides,LPS)、菌毛(Fimbriae)、外膜蛋白(Outer membrane proteins)、铁载体(Siderophores)、尿囊素(Allantoin)代谢相关因子及其基因组学研究进展进行综述,并对肺炎克雷伯氏菌研究中的一些问题进行探讨。
关键词:  肺炎克雷伯氏菌  致病菌  毒力因子  基因组学
DOI:10.13610/j.cnki.1672-352x.20200113.009
基金项目:四川省科技厅四川省科研院所科技成果转化资金(2017YSZH0008)和四川省科技厅应用基础研究项目 (2018JY0644)共同资助。
Progress on virulence factors and genomics in Klebsiella pneumoniae
ZHAO Wei,YU Dong,CHENG Jianguo,LI Qiubo,WANG Yin,YANG Zexiao,YAO Xueping,LUO Yan
(College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130;Sichuan Institute of Musk Deer Breeding, Dujiangyan 611800)
Abstract:
Klebsiella pneumoniae belongs to the Klebsiella genus of the Enterobacteriaceae, which is commonly associated with opportunistic infections and frequently isolated from respiratory and intestinal of human and animal, water, soil, forest products and agricultural products. As a commonly acknowledged pathogenic bacterium, K. pneumoniae has caused serious infection, including pneumonias, liver abscess, meningitis, enteritis, hysteritis, mastitis and septicemia, in human and animal. Besides, with the development of DNA sequencing technology, the mechanism of K. pneumoniae invades the host's immune system and causes disease has been revealed by whole genome sequencing. This review covers aspects of virulence factors (lipopolysaccharide, fimbriae, outer membrane proteins, siderophores and allantoin metabolism related factors) and genomics of K. pneumoniae. Meanwhile, some problems in research of K. pneumoniae have been discussed in this paper.
Key words:  Klebsiella pneumoniae   pathogenic bacterium  virulence factor  genomics

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