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蝉花宝牌蝉花片免疫功能评价
李成,彭国杰,金雷,李春如,樊美珍,孙长胜
0
(浙江泛亚生物医药股份有限公司,平湖 314200; 安徽农业大学林学与园林学院,合肥 230036;浙江泛亚生命科学研究院,平湖 314200)
摘要:
将蝉花宝牌蝉花片(商品名)设低、中、高3个剂量组,分别相当人体推荐量的5、10、30倍,同时设阴性对照组(1%羧甲基纤维素钠),连续1个月经口给予小鼠不同剂量的样品,进行迟发型超敏反应(DTH)、腹腔巨噬细胞吞噬鸡红细胞、抗体生成细胞检测、自然杀伤(NK)细胞杀伤活性和脾淋巴细胞转化等实验,以评估其免疫功能。结果表明,与阴性对照组比较,受试3个剂量组足跖肿胀度极显著增加(P<0.01);中、高剂量组溶血空斑数和血清溶血素抗体积数值均极显著增加(P<0.01),腹腔巨噬细胞吞噬鸡红细胞的吞噬率、吞噬指数显著增加(P<0.05,P<0.01);高剂量组NK细胞活性显著升高(P<0.05)。蝉花宝牌蝉花片(商品名)具有显著的免疫调节功能。
关键词:  虫草  蝉花  免疫功能  巨噬细胞吞噬  NK细胞活性
DOI:10.13610/j.cnki.1672-352x.20180302.007
基金项目:蝉花宝牌蝉花片(增免)保健食品报批项目资助。
Evaluating the immunity function of Chanhuabao tablet
LI Cheng,PENG Guojie,JIN Lei,LI Chunru,FAN Meizhen,SUN Changsheng
( Zhejiang BioAsia Bio-Pharmaceutical Co., Ltd, Pinghu 314200; School of Forestry and Landscape Architecture,Anhui Agricultural University, Hefei 230036;Zhejiang BioAsia Institute of Life Sciences, Pinghu 314200)
Abstract:
Mice were divided into one negative group (given 1% sodium carboxymethyl cellulose) and three treatment groups at different doses, i.e., low-dose, middle-dose and high-dose groups. Mice were fed with Chanhuabao tablets by five, ten and thirty times of the dose recommended to human beings for 4 weeks, respectively. The abilities of natural killer (NK) cells were tested. The delayed type hypersensitivity (DTH) test and splenic lymphocyte proliferation test were carried out thereafter. The results showed that compared to the negative group, the three treatment groups showed significant swelling of mice (P<0.01). The level of serum hemolysin (P<0.01), hemolytic plaque number (P<0.01) as well as the phagocytosis rate and phagocytic index (P<0.01) were significantly improved in the middle- and high-dose groups. The killing activity of NK cell was significantly increased in the high-dose group (P<0.05). In conclusion, Chanhuabao tablet could significantly improve the immunological function of mice.
Key words:  cordyceps  Isaria cicadae  immunological function  macrophage phagocytic activity  NK cell activity

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