| 摘要: |
| 为探讨胚胎晚期暴露细菌脂多糖（LPS）的中年CD-1小鼠背侧海马的类泛素化蛋白（SUMO-3）含量有无年龄相关性改变。采用免疫组织化学技术检测LPS暴露组和对照组CD-1小鼠背侧海马DG区、CA1区和CA3区各亚层的SUMO-3表达。结果表明，两组间各区各亚层的SUMO-3含量无明显差异。 |
| 关键词: 细菌脂多糖 免疫组织化学 背侧海马 类泛素化蛋白 |
| DOI：10.13610/j.cnki.1672-352x.20170419.023 |
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| 基金项目:国家自然科学基金（81370444）和安徽省高校自然科学研究项目（KJ2015A126）资助。 |
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| Effects of lipopolysaccharide on the SUMO-3 levels in doral hippocampus of middle-aged CD-1 mice during late embryon |
| YANG Qigang,CHEN Guihai |
| (Department of Critical Care Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei 230022;Department of Neurology and General Practice, Chaohu Hospital Affiliated of Anhui Medical University, Hefei 238000) |
| Abstract: |
| To explore the SUMO-3 levels in different subregions of dorsal hippocampus (DH) in the middle-aged CD-1 mice, we used immunohistochemical method to detect the expression of SUMO-3 in different DH subregions. The results showed that, in all sublayers of hippocampal DG, CA1 and CA3 regions, the SUMO-3 level of LPS-group was similar to those in the middle-aged mice of the control-group. There were no significant differences between the two groups in each sublayer of DG, CA1 and CA3 regions. |
| Key words: bacterial lipopolysaccharide immunohistochemical method dorsal hippocampus small ubiquitin-related modifier-3 |
