引用本文:[点击复制]
[点击复制]
【打印本页】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览次   下载 本文二维码信息
码上扫一扫!
磷酸吡哆醛补救途径两个关键酶的研究进展
黄龙全,张剑韵
0
(安徽农业大学茶与食品科技学院,合肥 230036;安徽农业大学外国语学院,合肥 230036)
摘要:
维生素B6(VB6)包括6个可相互转换的吡啶衍生物。其中,磷酸吡哆醛(PLP)作为140多种细胞酶的辅酶,在生物体内发挥重要作用。动物从食物中获得VB6,通过由吡哆醛激酶和磷酸吡哆醇氧化酶构成的补救途径合成PLP。PLP依赖酶的正常功能乃至人体最佳健康状态, 依赖于细胞中PLP的平衡供给。然而,就PLP的动态平衡和调节机制以及PLP合成后的转移机制而言,目前还知之甚少,是一个富有挑战性的研究领域。为此,综述PLP补救途径两个关键酶的研究进展。
关键词:  维生素B6  磷酸吡哆醛  补救途径  吡哆醛激酶  磷酸吡哆醇氧化酶
DOI:10.13610/j.cnki.1672-352x.20151102.011
基金项目:国家自然科学基金(31372262)资助。
Research advance in two key enzymes involved in the pyridoxal 5′-phosphate salvage pathway
HUANG Longquan,ZHANG Jianyun
(School of Tea and Food Science, Anhui Agricultural University, Hefei 230036;School of Foreign Languages, Anhui Agricultural University, Hefei 230036)
Abstract:
In six different vitamin B6 forms, pyridoxal 5′-phosphate (PLP) is a catalytically active form of VB6 It acts as cofactor in more than 140 different enzyme reactions. Animals obtain PLP form VB6 from diet and recycled it in a “salvage pathway”, which essentially involves two ubiquitous enzymes: pyridoxal kinase and pyridoxine5′-phosphate oxidase. Proper functioning of PLP-dependent enzymes and thus the optimal health of the human body are dependent upon an adequate level of PLP in the cell. However, the mechanism and regulation of PLP homeostasis, and the mechanism of addition of PLP to the apo-B6-enzymes are poorly understood and represent a very challenging research field. This article summarizes the current knowledge on the two enzymes involved in the PLP salvage pathway.
Key words:  vitamin B6  pyridoxal 5′-phosphate  salvage pathway  pyridoxal kinase  pyridoxine 5′-phosphate oxidase

用微信扫一扫

用微信扫一扫