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普洱茶中咖啡碱在小鼠体内的吸收情况研究
盛俊,张梁,张正竹
0
(安徽农业大学教育部/农业部茶叶生物化学与生物技术重点开放实验室,合肥 230036)
摘要:
对比研究了普洱茶、绿茶和咖啡碱以3种剂量(5、25和50 mg·kg-1·d-1)对小鼠灌胃给药之后,咖啡碱在小鼠体内的吸收情况。研究结果显示,以咖啡碱剂量为25和50 mg·kg-1·d-1,分别灌胃小鼠普洱茶、绿茶和咖啡碱纯品,普洱茶灌胃后小鼠血浆中咖啡碱的水平明显低于灌胃绿茶和咖啡碱组。同时,用AUC(30-150 min)梯形计算公式计算咖啡碱吸收总量,灌胃咖啡碱剂量为25和50 mg·kg-1·d-1的普洱茶血液中咖啡碱总量也明显小于灌胃绿茶和咖啡碱(P<0.05)。研究结果表明,相同咖啡碱剂量下,普洱茶中的其它成分能够显著抑制咖啡碱的体内吸收。
关键词:  普洱茶  绿茶  咖啡碱  小鼠  吸收
DOI:
投稿时间:2013-04-11
基金项目:教育部知名专家与创新团队发展计划(IRT1101)和国家自然科学基金(31201335)共同资助。
Absorption of caffeine in rats after orally administered with Pu-erh tea
SHENG Jun,ZHANG Liang,ZHANG Zheng-zhu
(Key Laboratory of Tea Biochemistry and Biotechnology, Ministry of Education, Ministry of Agriculture, Anhui Agricultural University, Hefei 230036)
Abstract:
Comparative study of caffeine absorption in mice after oral administration of Pu'er tea, green tea and caffeine with three caffeine dose (5, 25 and 50 mg·kg-1·d-1) was conducted. The results showed that the plasma concentration of caffeine after feeding Pu'er tea was significantly less than that after oral administration green tea and caffeine at the doses of 25 mg·kg-1·d-1 and 50 mg·kg-1·d-1. At the same time, the total absorption of caffeine was calculated by AUC(30-150 min)trapezoid formula. The total absorption of caffeine in plasma after administration of caffeine at the doses of 25 mg·kg-1·d-1 and 50 mg·kg-1·d-1 in the way of Pu'er tea was also significantly reduced after administration of caffeine at the doses of 25 mg·kg-1·d-1 and 50 mg·kg-1·d-1 in the way of green tea or caffeine (P<0.05). Research results suggested that the absorption of caffeine in Pu'er tea was significantly decreased.
Key words:  Pu'er tea  green tea  caffeine  mice  absorption

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