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镉代谢分子机制研究进展
蒋廷亚,周阳,林毅,魏凤娟,施海峰
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(江苏大学生命科学研究院,镇江 212013;安徽农业大学生命科学学院,合肥 230036)
摘要:
镉是一种人体非必需的重金属元素,镉的吸入会对人体产生许多不利影响,包括细胞癌变和凋亡等。现有的研究对镉的吸收、镉引起细胞毒性等领域的生化、分子机制做了大量工作,但对于镉在体内代谢的具体分子机制还不是很明晰,需要进一步阐释。该文讨论了镉的吸收和镉在体内的转运储存机制。并对镉与氧化应激,镉引起细胞凋亡的信号通路变化等研究进展进行了综述。
关键词:    代谢机制  细胞凋亡和癌变  信号通路
DOI:
基金项目:国家自然科学基金(31271272), 国家自然科学基金(31071030), 江苏省自然科学基金(BK2010328)和江苏大学高级人才基金(No. 1281330018)共同资助。
Research progress in molecular mechanism of cadmium metabolism
JIANG Ting-ya,ZHOU Yang,LIN Yin,WEI Feng-juan,SHI Hai-feng
(Institute of Life Sciences, Jiangsu University, Zhenjiang 212013;School of Life Sciences, Anhui Agricultural University, Hefei 230036)
Abstract:
Cadmium is a nonessential heavy metal, and human body exposed to cadmium will produce many adverse effects, including the cellular canceration and apoptosis, etc. Numerous studies focus on toxicity of cadmium, but the underlying cellular mechanisms of cadmium-induced organism toxicity remains elusive. In this review, based upon the major findings of previous reports related to cadmium and apoptotic cell death, we discuss process of cadmium research in transportation and its effect on cell apoptosis and signaling pathway in a system manner.
Key words:  cadmium  metabolism  cell apoptosis and canceration  signal pathway

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