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A Brief Review: Statistical Methodology for Mapping Quantitative Trait Loci
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摘要:
由于数量性状表型变异的连续性,无法用传统的孟德尔方法对单个数量性状位点(QTL)进行分离和定位。80年代初发现的DNA分子标记已被广泛应用于QTL的分离、定位及遗传效应估计,即QTL作图。统计学分析是实现QTL作图的一个重要环节。本文对80年代以来QTL作图统计方法的主要发展进行了简要综述。
关键词:  数量性状,QTL作图,DNA分子标记,统计方法的发展
DOI:
基金项目:
A Brief Review: Statistical Methodology for Mapping Quantitative Trait Loci
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Abstract:
Because of the continuity of phenotypic variation,it is not possible to dissect individual quantitative trait loci (QTLs) by traditional Mendelian method.DNA molecular markers discovered in early 1980s have been extensively used for estimating genomic positions and genetic effects of individual QTLs,namely QTL mapping.Statistical analysis is one major step for mapping QTLs.A brief review was given about the main development of statistical methodology for QTL mapping since the 1980s in this paper.
Key words:  Quantitative trait QTL mapping DNA markers Development of statistical methods

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