In order to effectively prevent the damage of Fusarium head blight in Chaohu City, Anhui Province, the average relative humidity, rain humidity and solar coefficient (rainy days × rainfall × the average relative humidity/sunshine time), rainfall and sunshine time from 2003 to 2019 were used as predictors, and the weighted contingency table analysis was used to predict the epidemic of Fusarium head blight before and after straw returning in 2011. The method was used to predict the occurrence of Fusarium head blight in Chaohu City, Anhui Province from 2020 to 2021. The predicted results of the model matched the actual occurrence of Fusarium head blight with a high accuracy of 100%. This method can be used to predict the occurrence degree of Fusarium head blight 50 - 60 d before the suitable period for control of wheat scab (wheat turning green period). The prediction method of wheat scab based on weighted contingency table analysis in this study can improve the accuracy of prediction of Fusarium head blight in Chaohu City, Anhui Province, and provide some references for the control of the disease.