The purpose of our research was to explore the therapeutic effect of seven anticoccidial drugs on Eimeria tenella Rongchang strain. In this study, 180 Roman pink roosters were randomly divided into 9 experimental groups by cage feeding until the age of 13 days, namely, acetamizuril group (EZL), diclazuril group (DIC), sulfachlorpyrazine sodium group (SUS), nicarbazine group (NIC), clopidol group (CLP), amprolium group (AML), decoquinate solution group (DQ), infection control group (PC) and blank control group (NC). Except the NC group, chickens in other groups were orally inoculated with 5×104 sporulated oocysts of Eimeria tenella Rongchang strain at the age of 14 days, and each drug group was mixed with feeding or drinking water one day before the inoculation until the end of the experiment. During the trial, the clinical manifestations of chickens in each group were observed, and the anti coccidial index (ACI) of the drug group was calculated by weight gain, survival rate, lesion value, oocyst value, etc. The results showed that chickens in EZL and DQ groups showed almost no clinical symptoms, and the cecal lesion score and oocyst production were significantly lower than those in other experimental groups. Their ACI were 184.00 and 189.50 respectively; The relative weight gain rate of SUS and NIC groups was higher, and their anti coccidia indexes were 136.00 and 124.06 respectively; The indexes of DIC, CLP and AML groups were poor, and their ACI were 123.50, 106.50 and 88.38 respectively. EZL and DQ are sensitive to Eimeria tenella Rongchang strain, and the effects of DIC, SUS and NIC are poor, while CLP and AML are ineffective.