为了建立红花药材中无机元素的电感耦合等离子体质谱分析方法，并对不同产地红花药材中无机元素进行分析测定，采用微波消解法对红花样品进行前处理，采用ICP-MS法测定不同产地红花中9种无机元素含量，并用SPSS 22.0软件对无机元素含量进行聚类分析。含量测定结果显示红花中含有丰富的无机元素，其中Mg、Ca含量最丰富，Fe、Mn、Cu含量次之，Cr、Co、Zn、Cd含量较少。方法学考察结果显示各元素的线性相关性良好，重复性和精密度的相对标准偏差(RSD)符合要求，加标回收率在96.2% ~ 109.5%；聚类分析结果显示32个产地的红花可分为两类：新疆和青海红花聚为一类；河南、山东、云南和甘肃的红花聚为一类。研究所建立的方法具有方便快捷、精确灵敏的优点，可为红花中无机元素的测定及质量标准的制定提供参考。
To establish a method for the determination of inorganic elements in Carthami Flos by microwave digestion-inductive coupled plasma mass spectrometry(ICP-MS), the microwave digestion technology was used to pretreat Carthami Flos samples, nine inorganic elements were determined by ICP-MS simultaneously, and the contents were analyzed by the statistical method with SPSS22.0 software. The result showed that there were rich inorganic elements in Carthami Flos, among which, Mg and Ca were the most abundant, Fe, Mn and Cu listed the second, and Cr, Co, Zn and Cd were less abundant. The linear correlation of each element was fine, the relative standard deviation (RSD) of repeatability and precision met the requirements, and the recoveries were in the range of 96.2% - 109.5%. Carthami Flos from 32 areas could be divided into two categories: Carthami Flos from Xinjiang and Qinghai were in the same category; Carthami Flos from other areas (Henan, Shandong, Yunnan and Gansu) belonged to the same category. The method is convenient and accurate, which is helpful for evaluating the quality and distinguishing the real producing area of Carthami Flos.