In recent years, high temperature occurs frequently during maize flowering in Huang-Huai-Hai area, which often causes the failure of kernel setting and thus affects maize grain yield and quality. High temperature stress during flowering has become one of the main limiting factors affecting the high and stable yield of maize. Based on current research progress, the climate change and characteristics of high temperature stress in recent years in Huang-Huai-Hai region were summarized. Based on the theory of source-sink relationship and the yield formation, the damage mechanism of high temperature stress during the flowering stage of maize were further analyzed. We also presented the cultivation measures of prevention and controlling high temperature stress from the aspects of variety selection, planting method, cultivation and water and fertilizer management. It was notable that high temperature stress at flowering stage is often accompanied by drought stress, which made it more difficult to comprehend the damage characteristics and mechanism, thus affecting the effective prevention and control of high temperature stress. Therefore, this paper pointed out that the mechanism of superimposed damage of high temperature and drought stress at flowering stage and its prevention and control measures will be the focus of future research on maize high and stable yield in Huang-Huai-Hai region.