To understand soil pH distribution characteristics and its relation to soil nutrients in Qianxi’nan tobacco-growing soil, soil pH status, spatial distribution, and its relationship to soil nutrients were analyzed using the methods of traditional statistics, geo-statistics, and grey correlation analysis. The results were as follows: (1) the pH of tobacco-growing soil is generally suitable for tobacco cultivation with a mean of 6.65 (ranged from 4.68 to 7.87) and a variation coefficient of 11.72%. About 51.04% of the soil samples showed a suitable soil pH for tobacco cultivation. (2) An extremely significant difference in tobacco-growing soil pH was observed between Anlong county and other counties. The soil pH values in different counties were ranked in an increasing order as follows: Anlong county＞Xingyi city＞Xingren county＞Zhenfeng county＞Qinglong county＞Pu’an county. (3) The pH was decreased with the rise of the soil stickiness. (4) IDW interpolation map indicated that the spatial pH distribution was patchiness and showed a reduced trend from the south to the north. The areas with low pH values were in Pu’an county and the areas with high pH values were in Anlong county. (5) An extremely significant or significant negative correlation between soil pH and ammonium nitrogen, nitric nitrogen, or available potassium was observed. (6) The order for the grey correlation between soil nutrient and pH was slowly available potassium＞available nitrogen＞organic matter＞available phosphorus＞total nitrogen＞total phosphorus＞available.