To find a feasible C and N management method in wheat field, the effect of carbon and nitrogen application method on the quality and yield of medium-gluten wheat ‘Wanmai 68’ in the southern region of the North China Plain was studied. The results showed that reduction of nitrogen fertilizer did not obviously decreased the wheat’s chlorophyll content and antioxidant enzyme activity during critical period for the growth of wheat; it also did not significantly lowered the yield and quality of ‘Wanmai 68’. Among all the carbon and nitrogen treatments, wheat received compost and organic fertilizer noticeably performed better than those applied with other fertilizers with the highest yield of 8988.2 kg·hm-2 and 8949.9 kg·hm-2, respectively. Application of compost and organic fertilizer could increase the antioxidant enzyme activity and chlorophyll content in wheat leaves in its later growth stage and increase 1000-kernel weight of wheat grain as well. In an addition, the quality of ‘Wanmai 68’ including protein content, bulk density, wet gluten content and flour yield are higher and more stable when compost fertilizer was used compared to other organic fertilizers. Meanwhile, application of crop stalks during the critical period lowered the chlorophyll content, antioxidant enzyme activity, yield, and quality of ‘Wanmai 68’. Results in this study suggest a great potential of decreasing nitrogen input in wheat production and direct returning crop stalk to the field might be a risk of decreasing wheat yield and quality in a short time. However, using compost and organic fertilizers could be an effective approach to greatly increase wheat yield and quality in this region.