This paper aims to screen the differentially expressed genes in fat synthesis associated with the fat deposition capacity in different pig-types, and to analyze their relationship with the expression of pig THRSP gene. The total RNA of the liver tissue samples from 5 lean- and 3 fat-type pigs were extracted, respectively. The differentially expressed genes were detected by using an Agilent microarray detection. The gene expression was related to THRSP gene. The results showed that comparing with lean-type pigs, the gene expressions of FASN, GLUT4 (P<0.01), and ACACA (P<0.05) in fat-type pigs were significantly up-regulated; and the gene expressions of Rab32 and Rab4a in small GTP enzyme were also significantly up-regulated, but Rab27a was significantly down-regulated (P<0.05). The expressions of the GLUT4, FASN and ACACA regulated genes related significantly to that of THRSP gene.