Biogas slurry fermented by manure sewage from scale livestock culture was used as organic fertilizer to study its effects on soil quality and yield and quality of Chinese cabbage. The pot experiment included 6 treatments with different fertilizer quantity. The results showed that all treatments improved the soil pH with different degrees. The contents of soil organic matter, available N and available K were positive correlated with biogas slurry quantity, and R values were 0.618, 0.637 and 0.710, respectively (P < 0.01), but there was no significant difference between the application of biogas slurry and available P. And the concentrations of soil heavy metals were lower than the criteria of National Soil Quality Standards for farmland and vegetable field, which mean the soil quality is safe under a single application of the highest dosage treatment (1080 t·hm^-2) in this experimental design. Application of biogas slurry could remarkably improve cabbage yield, promote mineral nutrient uptake and increase the Vc content, the soluble sugar content, however, the Cr, Zn and Cd contents in Chinese cabbage of T5 treatment exceeded all the National FoodSafetyStandard, indicating substantial digestion biogas slurry also need for further consideration of the accumulation of heavy metals of Cr, Zn and Cd in vegetables.