Puer tea has multiple biological effects. We study the regulation effect of Puer tea for anti-inflammation with the macrophage cell model, which derived from the THP-1 cell line stimulated by PMA (phorbol myristate acetate). The na?ve macrophage can secrete more IL-6 when treated with Puer tea. When macrophages treated with lipopolysaccharide (LPS) which stimulates the macrophages to produce IL-6 followed with Puer tea, the amount of IL-6 secreted by the macrophage was attenuated significantly, and the attenuate effect was dependent on the dose of Puer tea. This attenuate effect is EGCG independent. The present study suggest that Puer tea has dual-direction-regulation effect for the inflammation.