In this paper, Aspergillus niger was used to produce multi-enzyme enriched bio-feed from camellia oleifera seed cake with solid-state fermentation.The suitable medium for mixed fermentation of Aspergillus niger were soya bean meal to oil-tea-cake ratio of 1:1, material- to -water ratio of 1: 0.5, 1% (W/W)（NH₄）₂SO₄, 0.1% (W/W) K₂HPO₄, and 50 g dry material in 500 mL tapered bottle. The best fermentation conditions were 1.5% (W/W) inoculum size of Aspergillus niger, at 28℃ for 4 d at pH 5. The activities of proteinase and cellulase could reach to 4 128.1 U·g^-1 and 1 481.9 U·g^-1, respectively. The crude protein and the pure protein in camellia oleifera seed cake increased by 41.8%, 48.2%, respectively, while the crude fibre, tannin and tea saponin reduced by 38.0%, 78.7%, and 65.3%, respectively. Nutritional values of the fermented bio-feed improve obviously.