The taimen with initial body weight of 9.39±0.26 g were used to conducted a 56 days growth experiment for studying the effects of four feeding attractants（dimethyl-β-propiothetin, trimethylamine oxide, betaine and sodium-5’-inosinate）on feed intake, growth performance, body composition, digestive enzyme activities and serum indices. Fishes were raised in water flow system. There were 5 diets, and each diet was randomly assigned to triplicate groups of 50 fishes. During the experiment, the water temperature fluctuated from 9.3℃ to 14.2℃ and the dissolved oxygen was above 8.0 mg·L^-1. The results showed that the weight gain rate and specific growth rate of the taimen increased significantly by adding 0.2% dimethyl-β-propiothetin, 0.2% trimethylamine oxide, and 0.2% betaine, but there were no changes by supplementing 0.05% sodium-5’-inosinate（P>0.05）. The body crude protein increased significantly by supplementing 0.2% dimethyl-β-propiothetin (P<0.05), and body crude lipid decreased significantly by adding 0.2% trimethylamine oxide and 0.2% betaine (P<0.05), but body composition had no changes by supplementing 0.05% sodium-5’-inosinate (P>0.05).The digestive tract enzyme activities increased significantly by adding 0.2% dimethyl-β-propiothetin and 0.2% trimethylamine oxide（P<0.05）, and the digestive tract lipase increased significantly by supplementing 0.2% betaine (P<0.05), but digestive enzyme activities had no changes supplemented 0.05% sodium-5’-inosinate (P>0.05). The plasma total protein, albumin and globulin increased significantly when added 0.2% dimethyl-β-propiothetin (P<0.05), and the high density lipoprotein content increased, but cholesterol, triglyceride, low density lipoprotein decreased significantly when added 0.2% trimethylamine oxide and 0.2% betaine (P<0.05), and plasma complement 3 and complement 4 increased significantly supplemented 0.05% sodium-5’-inosinate (P<0.05). In conclusion, the food intake, growth performances, body composition and digestive ability of taimen were improved by adding the basal diets with 0.2% dimethyl-β-propiothetin, 0.2% trimethylamine oxide and 0.2% betaine, respectively (P<0.05), but not 0.05% sodium-5’-inosinate. The immunity of body were improved supplementing 0.05% sodium-5’-inosinate.